Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy
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1-s2.0-S2211124720311426-main.pdf
Description
Published version
Size
3.52 MB
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Adobe PDF
Checksum (MD5)
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Author(s)
Singh, Alveera
Kazer, Samuel W
Roider, Julia
Krista, Kami C
Millar, Jane
Asowata, Osaretin E
Ngoepe, Abigail
Ramsuran, Duran
Fardoos, Rabiah
Ardain, Amanda
Date Issued
2020
Journal
Cell Reports
Publisher
Elsevier BV
Citation
Singh, Alveera, Kazer, Samuel W, Roider, Julia, Krista, Kami C, Millar, Jane et al. 2020. "Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy." Cell Reports, 32 (11).
Version
Final published version
Abstract
© 2020 The Author(s) Innate lymphoid cells (ILCs) are important for response to infection and for immune development in early life. HIV infection in adults depletes circulating ILCs, but the impact on children infected from birth remains unknown. We study vertically HIV-infected children from birth to adulthood and find severe and persistent depletion of all circulating ILCs that, unlike CD4+ T cells, are not restored by long-term antiretroviral therapy unless initiated at birth. Remaining ILCs upregulate genes associated with cellular activation and metabolic perturbation. Unlike HIV-infected adults, ILCs are also profoundly depleted in tonsils of vertically infected children. Transcriptional profiling of remaining ILCs reveals ongoing cell-type-specific activity despite antiretroviral therapy. Collectively, these data suggest an important and ongoing role for ILCs in lymphoid tissue of HIV-infected children from birth, where persistent depletion and sustained transcriptional activity are likely to have long-term immune consequences that merit further investigation.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
Ragon Institute of MGH, MIT and Harvard
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Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1016/J.CELREP.2020.108153
