Environmental and age effects on methylation changes in human brain and blood cells
Name
894225376-MIT.pdf
Description
Full printable version
Size
8.26 MB
Format
Adobe PDF
Checksum (MD5)
7021f0c556954c48e72d8e32af90999a
Author(s)
Giguzinsky, Orit
Advisor(s)
Manolis Kellis.
Date Issued
2014
Publisher
Massachusetts Institute of Technology
Abstract
Previous studies have shown that DNA methylation may 1 e associated with disease, aging, the rate of aging and genetics. In this thesis, age is accurately predicted from DNA methylation in brain and blood tissues using two different algorithms, Random Forest and Linear Regression. Relationships between DNA methylation, genetics, disease and aging rate were also identified. Furthermore, the differences between the real ages and the predicted ages were found to be associated with the age of onset of aging related disease. The findings presented in this thesis take us a step further in understanding the causes of aging and age related disease and further prove the theory that methylation is related to our internal biological clock and disease.
Description
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 125-129).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
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