All models are wrong, but some organoids may be useful
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13059_2019_Article_1677.pdf
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301.55 KB
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Author(s)
Mead, Benjamin Elliott
Karp, Jeffrey Michael
Date Issued
March 2019
Journal
Genome Biology
Publisher
Springer Nature
Citation
Mead, Benjamin E. and Jeffrey M. Karp. "All models are wrong, but some organoids may be useful." Genome Biology 20,1 (March 2019):66
Version
Final published version
Abstract
Modeling is an essential part of the scientific method. A model enables us to learn about our surroundings by simplifying a complex observation to a set of principles—conceptual or operational—and, in the process, allows for the extension and testing of ‘observable truths’. In the life sciences, biological models have a particularly long history and still play an essential role. They include small animal models that are used widely in genetics and developmental biology, large animal models for therapeutic development, and cellular models that are used to study disease and to develop new medicines.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Chemistry
Harvard University--MIT Division of Health Sciences and Technology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1186/s13059-019-1677-4
