Anaplastic nephroblastoma with peritoneal metastasis in an adult female Sprague Dawley rat
Name
33_2020-0030.pdf
Description
Published version
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2.69 MB
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Unknown
Checksum (MD5)
97e0e2dc15f0aa8be889ac9058f0c597
Author(s)
Quinn, Lisa
Fox, James G
Joy, Joanna
Muthupalani, Sureshkumar
Carrasco, Sebastian E.
Date Issued
2020
Journal
Journal of Toxicologic Pathology
Publisher
Japanese Society of Toxicologic Pathology
Version
Final published version
Abstract
© 2020 The Japanese Society of Toxicologic Pathology. Spontaneous nephroblastomas are uncommon tumors of laboratory rats. This report describes a spontaneous nephroblas-toma with peritoneal metastasis in an 11-month-old, female Sprague Dawley rat. The rat was part of a breeding program and presented 15 days post parturition with clinical signs including tachypnea, dyspnea and abdominal distension. At necropsy, the right kidney was markedly enlarged by an expansile pale-tan to white multinodular mass with extension into the retroperitoneal space, with multifocal variably sized nodules involving the mesentery, and surface of pancreas, liver, uterus, and ovarian bursa. The rat also had severe bicavi-tary effusion. Histologically, the renal parenchyma of the affected kidney was replaced by a moderately cellular, poorly-demarcated, non-encapsulated, multilobulated mass that appeared to compress the adjacent renal outer medulla and cortex. Three distinct neoplas-tic cell populations were identified in this renal tumor: epithelial cells (convoluted and dilated tubules / rare primitive glomeruloid structures), mesenchymal (neoplastic spindle cells in connective tissue), and blastemal cells (primitive neoplastic cells). The extrarenal nodular masses were predominantly composed of neoplastic mesenchymal and pleomorphic blastemal cells. Immunohistochemically, neoplastic epithelial cells in the renal mass were positive for pancytokeratin, and blastemal cells in both renal and extrarenal masses were positive for Wilms’ tumor 1 protein (WT1) and vimentin. Neoplastic mesenchymal elements in both renal and extrarenal masses were positive for vimentin. The neoplasm was negative for chromogranin A and S100. The tumor was classified as an anaplastic nephro-blastoma with metastasis to the mesentery and peritoneal organs.
MIT Department
Massachusetts Institute of Technology. Division of Comparative Medicine
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DOI of Published Version
https://doi.org/10.1293/TOX.2020-0030
