Measuring light transport properties using speckle patterns as structured illumination
Name
s41598-019-47256-8.pdf
Description
Published version
Size
2.86 MB
Format
Adobe PDF
Checksum (MD5)
e89bcfb7dc366a648bdd39169643241f
Author(s)
Jain, Prabhat
Sarma, Sanjay E
Date Issued
August 1, 2019
Journal
Scientific reports
Publisher
Springer Science and Business Media LLC
Citation
Jain, Pranay and Sanjay e. Sarma. "Measuring light transport properties using speckle patterns as structured illumination." Scientific reports 9(2019):11157 ©2019 The Author(s)
Version
Final published version
Abstract
The measurement of light absorption and scattering properties of biological materials has several diagnostic and therapeutic applications. We can measure these properties for skin without contact using structured illumination and imaging. However, building simple handheld devices remains challenging due to motion artefacts and moving targets. To overcome this limitation, we project random speckle patterns instead of discrete spatial frequencies on the target. Since random patterns are spatially broadband, they capture more information per image, enabling frame-by-frame analysis. In this paper, we describe the statistics of objective speckles and demonstrate how the optical system is designed for spatially bandlimited illumination. Next, we use a diverse set of liquid tissue phantom to validate the method. We successfully demonstrate that a calibrated instrument can independently predict the two primary light transport properties of a homogeneous turbid system. This work is a starting point for analysing skin and other heterogeneous biological media in the future.
Subjects
Multidisciplinary
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/s41598-019-47256-8
