Evolution of macromolecular complexity in drug delivery systems
Name
nihms-1011032.pdf
Description
Accepted version
Size
1.3 MB
Format
Adobe PDF
Checksum (MD5)
41ca4f1afc21854706ebf8042e716494
Author(s)
Kakkar, Ashok
Traverso, Giovanni
Farokhzad, Omid C
Weissleder, Ralph
Langer, Robert
Date Issued
2017
Journal
Nature Reviews Chemistry
Publisher
Springer Science and Business Media LLC
Version
Author's final manuscript
Abstract
© 2017 Macmillan Publishers Limited. Designing therapeutics is a process with many challenges. Even if the first hurdle-designing a drug that modulates the action of a particular biological target in vitro-is overcome, selective delivery to that target in vivo presents a major barrier. Side-effects can, in many cases, result from the need to use higher doses without targeted delivery. However, the established use of macromolecules to encapsulate or conjugate drugs can provide improved delivery, and stands to enable better therapeutic outcomes. In this Review, we discuss how drug delivery approaches have evolved alongside our ability to prepare increasingly complex macromolecular architectures. We examine how this increased complexity has overcome the challenges of drug delivery and discuss its potential for fulfilling unmet needs in nanomedicine.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/S41570-017-0063
