Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy
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12265_2021_Article_10181.pdf
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1.5 MB
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Unknown
Checksum (MD5)
4f0333cc193db5f039acd190fdea3070
Author(s)
Marlevi, David
Date Issued
December 9, 2021
Journal
Journal of Cardiovascular Translational Research
Publisher
Springer US
Citation
Marlevi, David, Mariscal-Harana, Jorge, Burris, Nicholas S., Sotelo, Julio, Ruijsink, Bram et al. 2021. "Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy."
Version
Final published version
Abstract
Abstract
Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol.
Graphic Abstractr
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1007/s12265-021-10181-1
