Interfacing devices with cells
Name
Voldman_Interfacing devices.pdf
Size
1.35 MB
Format
Adobe PDF
Checksum (MD5)
222371c14357aa05d764d67df01f6051
Author(s)
Voldman, Joel
Date Issued
December 2009
Journal
Device Research Conference, 2009. DRC 2009
Publisher
Institute of Electrical and Electronics Engineers
Citation
Voldman, J. “Interfacing devices with cells.” Device Research Conference, 2009. DRC 2009. 2009. 243-244. ©2009 IEEE.
Version
Author's final manuscript
Abstract
To detect electrical properties of cells, we have developed a method called iso-dielectric separation (IDS), where cells are placed in a spatially varying electric field and a spatially varying conductivity gradient that forces them to the location in a channel where their net polarizability (p) is zero. At that location, the force on the cell, given by the dielectrophoretic force (F = p . delta E) will go to zero. Cells with different polarizabilities will end up in different locations in the channel, thus separating cells based upon electrical properties. The physical implementation of the method is described in Figure 3, and consists of a glass chip with patterned electrodes to create the field, along with microfluidics to deliver cells and create the conductivity gradient.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Attribution-Noncommercial-Share Alike 3.0 Unported
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/DRC.2009.5354848
