Synthetic biology by controller design
Name
Current_Opinion_Biotech_2022(1).pdf
Description
Accepted version
Size
388.79 KB
Format
Adobe PDF
Checksum (MD5)
93d5d846336b5d914d3c167359991f2b
Author(s)
Barajas, Carlos
Del Vecchio, Domitilla
Date Issued
December 2022
Journal
Current Opinion in Biotechnology
Publisher
Elsevier BV
Citation
Barajas, Carlos and Del Vecchio, Domitilla. 2022. "Synthetic biology by controller design." Current Opinion in Biotechnology, 78.
Version
Author's final manuscript
Abstract
Natural biological systems display complex regulation and synthetic biomolecular systems have been used to understand their natural counterparts and to parse sophisticated regulations into core design principles. At the same time, the engineering of biomolecular systems has unarguable potential to transform current and to enable new, yet-to-be-imagined, biotechnology applications. In this review, we discuss the progression of control systems design in synthetic biology, from the purpose of understanding the function of naturally occurring regulatory motifs to that of creating genetic circuits whose function is sufficiently robust for biotechnology applications.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-ShareAlike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.copbio.2022.102837
