Smart Microgel Studies. Interaction of Polyether-Modified Poly(Acrylic Acid) Microgels with Anticancer Drugs
Name
MEBCS026.pdf
Size
1.19 MB
Format
Adobe PDF
Checksum (MD5)
732b0b583cde3b90680f1d45002eb00d
Author(s)
Bromberg, Lev
Hatton, T. Alan
Date Issued
January 2003
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
Studies of submillimeter gels composed of covalently cross-linked poly(acrylic acid)-g-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (Pluronic-PAA) networks are reviewed in light of potential applications of the microgels as drug carriers in oral delivery. The microgels are capable of volumetric transitions in response to environmental stimulae such as pH and temperature. It is shown that the type of Pluronic used in the microgel synthesis changes the structure of the resulting microgels, with the more hydrophobic Pluronic imparting porosity. Microgels based on Pluronic L92 (L92-PAA-EGDMA) possess higher ion-exchange capacity than microgels based on Pluronic F127 (F127-PAA-EGDMA), albeit the former are more hydrophobic. Analogously, more hydrophobic but heterogeneous L92-PAA-EGDMA exhibit superior capacity for equilibrium loading of hydrophobic drugs such as taxol, camptothecin and steroid hormones, as well as higher capacity for weakly basic drugs such as doxorubicin, mitomycin C, and mitoxantrone.
Subjects
anticancer drugs
hydrophobic solutes
oral drug delivery
smart microgels
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