MicroRNAs Modulate Hematopoietic Lineage Differentiation
Name
MEBCS012.pdf
Size
1.55 MB
Format
Adobe PDF
Checksum (MD5)
75c0825e62e0c3dc091264d0f6872032
Author(s)
Lodish, Harvey F.
Chen, Chang-Zheng
Bartel, David P.
Date Issued
January 2005
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
MicroRNAs (miRNAs), an abundant class of ~22 nucleotide non-coding RNAs, are thought to play an important regulatory role in animal and plant development at the posttranscriptional level. Many miRNAs cloned from mouse bone marrow cells are differentially regulated in various hematopoietic lineages, suggesting that they might influence hematopoietic lineage differentiation. Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia. miR-181, a miRNA upregulated only in the B cell lineage of mouse bone marrow cells, promotes B cell differentiation and inhibits production of CD8⁺ T cells when expressed in hematopoietic stem/progenitor cells. In contrast miR-142s inhibits production of both CD4⁺ and CD8⁺ T cells and does not affect B cells. Collectively, these results indicate that microRNAs are components of the molecular circuitry controlling mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development.
Subjects
microRNA
B cells
T cells
leukemia
lymphoma
stem cells
CD4+
CD8+
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