Electrokinetic Motion of Neurotransmitter Ions through a 1.01 nm Diameter Single-Walled Carbon Nanotube
Name
electrokinetic-motion-of-neurotransmitter-ions-through-a-1-01-nm-diameter-single-walled-carbon-nanotube.pdf
Description
Published version
Size
8.94 MB
Format
Adobe PDF
Checksum (MD5)
c545ee646b56c05facd98adfa30e827c
Author(s)
Ellison, Mark D
Allen, Jacqueline
Bonfiglio, Michael
Seeburger, Matthew
Setenet, Jean
DiGinto, Biagio
Bonanny, Harrison
Russell, Aaliyah
Baird, David
Davis, Liana
Date Issued
March 11, 2025
Journal
The Journal of Physical Chemistry C
Publisher
American Chemical Society
Citation
Mark D. Ellison, Jacqueline Allen, Michael Bonfiglio, Matthew Seeburger, Jean Setenet, Biagio DiGinto, Harrison Bonanny, Aaliyah Russell, David Baird, Liana Davis, Ella McCarthy, Alyson Manley, Sarah Blatt, David Lippe, Daniel Ragone, Brock Dyer, Jillian Osgood, and Michael S. Strano. The Journal of Physical Chemistry C 2025 129 (11), 5472-5482.
Version
Final published version
Abstract
The transport of cations of the neurotransmitters acetylcholine, choline, and dopamine through a 1.01 nm-diameter, 1.1 mm-long single-walled carbon nanotube (SWNT) has been studied for the first time. As a comparison, sodium and aniline ion transport was also investigated. All of these ions exhibited significantly enhanced electrophoretic mobilities over bulk transport. The electrophoretic mobilities of acetylcholine, choline, and sodium were found to depend on pH, specifically increasing as pH decreases. This result is explained by hydrogen ions saturating the surface charges of the SWNT. Conversely, dopamine and aniline have mobilities that do not depend on pH. This difference is attributed to the benzene ring and the size of these ions. An analysis of the time required for an ion to traverse the nanotube shows that the ions adsorb to and desorb from the walls as they pass through the tube. Acetylcholine, choline, and sodium show desorption rate constants that decrease with increasing pH, whereas dopamine and aniline have rate constants that remain constant over different pH values. This is consistent with the relationship between adsorption and desorption rate constants and mobility from an adsorption/desorption kinetic model.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution
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DOI of Published Version
10.1021/acs.jpcc.4c07482
