Molecular Control of Induced Pluripotency
Name
Jaenisch_Molecular control.pdf
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2.17 MB
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Adobe PDF
Checksum (MD5)
29f43af930748b341bf08b9a230c5eca
Author(s)
Theunissen, Thorold W.
Jaenisch, Rudolf
Date Issued
June 2014
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Theunissen, Thorold W., and Rudolf Jaenisch. “Molecular Control of Induced Pluripotency.” Cell Stem Cell 14, no. 6 (June 2014): 720-734.
Version
Author's final manuscript
Abstract
Deciphering the mechanisms of epigenetic reprogramming provides fundamental insights into cell fate decisions, which in turn reveal strategies to make the reprogramming process increasingly efficient. Here we review recent advances in epigenetic reprogramming to pluripotency with a focus on the principal molecular regulators. We examine the trajectories connecting somatic and pluripotent cells, genetic and chemical methodologies for inducing pluripotency, the role of endogenous master transcription factors in establishing the pluripotent state, and functional interactions between reprogramming factors and epigenetic regulators. Defining the crosstalk among the diverse molecular actors implicated in cellular reprogramming presents a major challenge for future inquiry.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.stem.2014.05.002
