Optical coherence tomography angiography
Name
1-s2.0-S1350946217300563-main.pdf
Description
Published version
Size
20.3 MB
Format
Adobe PDF
Checksum (MD5)
5c151f24c3bf52555ea1445eea9e9837
Author(s)
Spaide, Richard F.
Fujimoto, James G.
Waheed, Nadia K.
Sadda, Srinivas R.
Staurenghi, Giovanni
Date Issued
May 2018
Journal
Progress in Retinal and Eye Research
Publisher
Elsevier BV
Citation
Spaide, Richard F. et al. "Optical coherence tomography angiography." Progress in Retinal and Eye Research 64 (May 2018): 1-55 © 2018 The Authors
Version
Final published version
Abstract
Optical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and rapid advancements in both imaging and in our understanding of the imaging and applicable pathophysiology of the retina and choroid. These factors lead to a steep learning curve, even for those with a working understanding dye-based ocular angiography. All for a method of imaging that is a little more than 10 years old. This review begins with a historical account of the development of OCTA, and the methods used in OCTA, including signal processing, image generation, and display techniques. This forms the basis to understand what OCTA images show as well as how image artifacts arise. The anatomy and imaging of specific vascular layers of the eye are reviewed. The integration of OCTA in multimodal imaging in the evaluation of retinal vascular occlusive diseases, diabetic retinopathy, uveitis, inherited diseases, age-related macular degeneration, and disorders of the optic nerve is presented. OCTA is an exciting, disruptive technology. Its use is rapidly expanding in clinical practice as well as for research into the pathophysiology of diseases of the posterior pole. Keywords: Multimodal imaging; Optical coherence tomography; Optical coherence tomography angiography
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.preteyeres.2017.11.003
