Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules
Name
nihms756828.pdf
Description
Accepted version
Size
1.45 MB
Format
Adobe PDF
Checksum (MD5)
ffa9139bc90623690be657cdea2d5bcd
Author(s)
O'Shea, Timothy M
Webber, Matthew J
Aimetti, Alex A
Langer, Robert
Date Issued
2015
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
O'Shea, T. M., et al. "Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules." Adv Healthc Mater (2015).
Version
Author's final manuscript
Abstract
Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and -controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and -lyophilization stressors. Strong and -ordered hydrogen bonding interactions within covalently incorporated trehalose hydrogels represent a possible mechanism for protein stabilization.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
10.1002/ADHM.201500334
https://doi.org/10.1002/ADHM.201500334
