Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers
Name
MEBCS027.pdf
Size
328.02 KB
Format
Adobe PDF
Checksum (MD5)
5eac62909be52636942679530a997aa6
Author(s)
Deshmukh, Smeet
Bromberg, Lev
Hatton, T. Alan
Date Issued
January 2004
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
Facile, one-step synthesis of self-assembling, cationic block copolymers of poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and PEO-PPO-PEO (Pluronic®) is developed. The copolymers are obtained via free-radical polymerization of DMAEMA initiated by Pluronic-radicals generated by cerium (IV). The copolymers possess surface activity, are polycationic at pH<7.1, and self-assemble into micelle-like aggregates when neutralized. Potential applications of the novel copolymers for DNA transfection in gene therapy are discussed.
Subjects
poly(2-N-(dimethylaminoethyl) methacrylate) Pluronic®
cerium (IV)
free-radical polymerization
self-assembly
gene therapy
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