Laminarly Orthogonal Excitation of Fast-Spiking and Low-Threshold-Spiking Interneurons in Mouse Motor Cortex
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Apicella-2012-Laminarly orthogonal.pdf
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Author(s)
Apicella, Alfonso J.
Wickersham, Ian R.
Seung, H. Sebastian
Shepherd, Gordon M. G.
Date Issued
May 2012
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Apicella, A. J. et al. “Laminarly Orthogonal Excitation of Fast-Spiking and Low-Threshold-Spiking Interneurons in Mouse Motor Cortex.” Journal of Neuroscience 32.20 (2012): 7021–7033.
Version
Final published version
Abstract
In motor cortex, long-range output to subcortical motor circuits depends on excitatory and inhibitory inputs converging on projection neurons in layers 5A/B. How interneurons interconnect with these projection neurons, and whether these microcircuits are interneuron and/or projection specific, is unclear. We found that fast-spiking interneurons received strong intralaminar (horizontal) excitation from pyramidal neurons in layers 5A/B including corticostriatal and corticospinal neurons, implicating them in mediating disynaptic recurrent, feedforward, and feedback inhibition within and across the two projection classes. Low-threshold-spiking (LTS) interneurons were instead strongly excited by descending interlaminar (vertical) input from layer 2/3 pyramidal neurons, implicating them in mediating disynaptic feedforward inhibition to both projection classes. Furthermore, in a novel pattern, lower layer 2/3 preferentially excited interneurons in one layer (5A/LTS) and excitatory neurons in another (5B/corticospinal). Thus, these inhibitory microcircuits in mouse motor cortex follow an orderly arrangement that is laminarly orthogonalized by interneuron-specific, projection-nonspecific connectivity.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Media Laboratory
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DOI of Published Version
https://doi.org/10.1523/jneurosci.0011-12.2012
