Rostro-Caudal Inhibition of Hindlimb Movements in the Spinal Cord of Mice
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Bizzi_Rostro Caudal.pdf
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Author(s)
Caggiano, Vittorio
Bizzi, Emilio
Sur, Mriganka
Date Issued
June 2014
Journal
PLoS ONE
Publisher
Public Library of Science
Citation
Caggiano, Vittorio, Mirganka Sur, and Emilio Bizzi. “Rostro-Caudal Inhibition of Hindlimb Movements in the Spinal Cord of Mice.” Edited by Simone Di Giovanni. PLoS ONE 9, no. 6 (June 25, 2014): e100865.
Version
Final published version
Abstract
Inhibitory neurons in the adult mammalian spinal cord are known to locally modulate afferent feedback - from muscle proprioceptors and from skin receptors - to pattern motor activity for locomotion and postural control. Here, using optogenetic tools, we explored how the same population of inhibitory interneurons globally affects hindlimb movements in the spinal cord of both anesthetized and freely moving mice. Activation of inhibitory interneurons up to the middle/lower spinal cord i.e. T8–T9, were able to completely and globally suppress all ipsilateral hindlimb movements. Furthermore, the same population of interneurons - which inhibited movements - did not significantly change the sensory and proprioceptive information from the affected limbs to the cortex. These results suggest a rostro-caudal organization of inhibition in the spinal cord motor output without modulation of ascending sensory pathways.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Picower Institute for Learning and Memory
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Creative Commons Attribution
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DOI of Published Version
http://dx.doi.org/10.1371/journal.pone.0100865
