Studies directed toward the synthesis of the B-type amphidinolide natural products using nickel-catalyzed reductive couplings of enynes and carbonyl compounds
Name
655319475-MIT.pdf
Description
Full printable version
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9.59 MB
Format
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Checksum (MD5)
e00934fe814332ab03740a96a26f253a
Author(s)
Lauer, Andrew M. (Andrew Michael)
Advisor(s)
Timothy F. Jamison.
Date Issued
2010
Publisher
Massachusetts Institute of Technology
Abstract
Progress coupling of substrates, toward the total synthesis of amphidinolide B1 is described. The reductive 1,3-eynes and ketones was explored. It was found to work well with simple but failed to yield intermediates toward amphidinolide B1 [images] ... The coupling of 1,3-enyne and aldehyde fragments toward the synthesis of amphidinolides G3 and H4 is also described. The entire carbon skeleton of these natural products has been prepared from this coupling and a subsequent installation of a methyl group using an indium based reagent ... [images].
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references.
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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