Characterization of nanofilter arrays for small molecule separation
Name
143822801-MIT.pdf
Description
Full printable version
Size
9.5 MB
Format
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Checksum (MD5)
8ada6a87ee11fc9ad6bff170db2d3cfb
Author(s)
Bow, Hansen Chang
Advisor(s)
Jongyoon Han.
Date Issued
2006
Publisher
Massachusetts Institute of Technology
Abstract
Experimental studies were performed to evaluate methods of improving separation resolution and speed in microfabricated nanofilter arrays. Experiment parameters investigated include electric field strength, nanofilter geometry, and buffer concentration. DNA polymers of size 25-1000 base pairs were the subject of our study. We concluded that increasing electric field strength resulted in inferior separation for larger DNA polymers (400-1000 bp). Additionally, we quantified the improvement in resolution of smaller nanofilter pores and lower buffer concentration. A theoretical model based on Macrotransport Theory was developed to estimate average species velocity and peak dispersion.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.
Includes bibliographical references (p. 59-60).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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