7.343 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease, Fall 2007
Author(s)
Rai, Priyamvada
Alternative Title
The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease
Date Issued
December 2007
Abstract
This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Subjects
reactive oxygen species
oxygen
ROS
energy
mitochondria
cell signaling
anti-pathogen
oxidative damage
oncogene
antioxidant
insulin resistance
diabetes
stem cell
neurodegenerative
ischemic
ATP
pathways
NADPH
nox
psd
programmed cell death
apoptosis
hsc
hematopoietic
MIT Department
Massachusetts Institute of Technology. Department of Biology
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