The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
Name
The endoplasmic reticulum may be an Achilles heel of cancer cells that have undergone an epithelial to mesenchymal transition.pdf
Size
1.64 MB
Format
Adobe PDF
Checksum (MD5)
aeb69b8250792fcd043b962a83ea44b8
Author(s)
Feng, Yu-xiong
Sokol, Ethan Samuel
Gupta, Piyush
Date Issued
October 2014
Journal
Molecular & Cellular Oncology
Publisher
Informa UK Limited
Citation
Feng, Yu-xiong et al. “The Endoplasmic Reticulum May Be an Achilles’ Heel of Cancer Cells That Have Undergone an Epithelial-to-Mesenchymal Transition.” Molecular & Cellular Oncology 1, 2 (June 2014): e961822 © 2014 The Authors
Version
Final published version
Abstract
In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings. Keywords: EMT; ER stress; UPR
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial 3.0 Unported
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DOI of Published Version
https://doi.org/10.4161/23723548.2014.961822
