The determination of hemocompatibility of a geometrically-altered poly(dimethylsiloxane) surface
Name
62588883-MIT.pdf
Description
Full printable version
Size
2.69 MB
Format
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Checksum (MD5)
24f8ef5bda95bb96b5e29050d0d4d256
Author(s)
Becker, Geoffrey A
Advisor(s)
Nam Pyo Suh.
Date Issued
2005
Publisher
Massachusetts Institute of Technology
Abstract
Bio- and hemocompatibility are some of the driving forces behind medical device creation and materials science in this day and age. An experimental study was performed to test whether a geometrically altered surface of Poly(dimethylsiloxane), or PDMS, was found to be more or less hemocompatible than a flat, unaltered film of PDMS. In this case, the alteration was the addition of micron-scale posts sticking perpendicular to the surface, creating a superhydrophobic "bed of nails" effect. Once the specific altered surfaces were chosen, designed using Photolithography, and manufactured via a polymer casting process, a platelet adhesion assay was developed to assess the relative hemocompatibility of the surface via number of platelets counted on the surface of the altered vs. unaltered PDMS. Apparent contact angles of blood and Platelet-Rich Plasma (PRP) on the surface were also measured. The final instance of this experiment yielded positive results: The geometrically altered surface yielded less debris and platelet adhesion than did the flat PDMS surface, indicating an improvement in the hemocompatibility of PDMS via this process.
Description
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.
Includes bibliographical references (leaves 38-40).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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