Mechanics in medicine
Name
USNCTAM Mechanics in Medicine Mar 15 2014.pdf
Size
2.33 MB
Format
Adobe PDF
Checksum (MD5)
40e8692ada0ce008bacaa06638d4d052
Author(s)
Bao, Gang
Bazilevs, Yuri
Chung, Jae-Hyun
Decuzzi, Paolo
Espinosa, Horacio D.
Ferrari, Mauro
Gao, Huajian
Hossain, Shaolie S.
Hughes, Thomas J. R.
Kamm, Roger Dale
Alternative Title
USNCTAM perspectives on mechanics in medicine
Date Issued
May 2014
Journal
Journal of The Royal Society Interface
Publisher
Royal Society
Citation
Bao, G., Y. Bazilevs, J.-H. Chung, P. Decuzzi, H. D. Espinosa, M. Ferrari, H. Gao, et al. “USNCTAM Perspectives on Mechanics in Medicine.” Journal of The Royal Society Interface 11, no. 97 (May 21, 2014): 20140301–20140301.
Version
Original manuscript
Abstract
Over decades, the theoretical and applied mechanics community has developed sophisticated approaches for analysing the behaviour of complex engineering systems. Most of these approaches have targeted systems in the transportation, materials, defence and energy industries. Applying and further developing engineering approaches for understanding, predicting and modulating the response of complicated biomedical processes not only holds great promise in meeting societal needs, but also poses serious challenges. This report, prepared for the US National Committee on Theoretical and Applied Mechanics, aims to identify the most pressing challenges in biological sciences and medicine that can be tackled within the broad field of mechanics. This echoes and complements a number of national and international initiatives aiming at fostering interdisciplinary biomedical research. This report also comments on cultural/educational challenges. Specifically, this report focuses on three major thrusts in which we believe mechanics has and will continue to have a substantial impact. (i) Rationally engineering injectable nano/microdevices for imaging and therapy of disease. Within this context, we discuss nanoparticle carrier design, vascular transport and adhesion, endocytosis and tumour growth in response to therapy, as well as uncertainty quantification techniques to better connect models and experiments. (ii) Design of biomedical devices, including point-of-care diagnostic systems, model organ and multi-organ microdevices, and pulsatile ventricular assistant devices. (iii) Mechanics of cellular processes, including mechanosensing and mechanotransduction, improved characterization of cellular constitutive behaviour, and microfluidic systems for single-cell studies.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1098/rsif.2014.0301
