RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract
Name
scirobotics.abp9066.pdf
Description
Published version
Size
1.2 MB
Format
Adobe PDF
Checksum (MD5)
ce51940f7f81db850f51349f034f4c81
Author(s)
Srinivasan, Shriya S.
Alshareef, Amro
Hwang, Alexandria V.
Kang, Ziliang
Kuosmanen, Johannes
Ishida, Keiko
Jenkins, Joshua
Liu, Sabrina
Madani, Wiam Abdalla Mohammed
Lennerz, Jochen
Date Issued
September 28, 2022
Journal
Science Robotics
Publisher
American Association for the Advancement of Science
Citation
Shriya S. Srinivasan et al. ,RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract.Sci. Robot.7,eabp9066(2022).
Version
Final published version
Abstract
Oral drug delivery of proteins is limited by the degradative environment of the gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs. Luminal mucus represents the initial steric and dynamic barrier to absorption. To overcome this barrier, we report the development of the RoboCap, an orally ingestible, robotic drug delivery capsule that locally clears the mucus layer, enhances luminal mixing, and topically deposits the drug payload in the small intestine to enhance drug absorption. RoboCap’s mucus-clearing and churning movements are facilitated by an internal motor and by surface features that interact with small intestinal plicae circulares, villi, and mucus. Vancomycin (1.4 kilodaltons of glycopeptide) and insulin (5.8 kilodaltons of peptide) delivery mediated by RoboCap resulted in enhanced bioavailability 20- to 40-fold greater in ex vivo and in vivo swine models when compared with standard oral delivery (P < 0.05). Further, insulin delivery via the RoboCap resulted in therapeutic hypoglycemia, supporting its potential to facilitate oral delivery of drugs that are normally precluded by absorption limitations.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Division of Comparative Medicine
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/scirobotics.abp9066
