Formulations for trans-tympanic antibiotic delivery
Name
nihms-417742.pdf
Description
Accepted version
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1.64 MB
Format
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Checksum (MD5)
62c4e9e179de2337257cb3ae6630d65e
Author(s)
Khoo, Xiaojuan
Simons, Emmanuel John
Chiang, Homer H.
Hickey, Julia M.
Sabharwal, Vishakha
Pelton, Stephen I.
Rosowski, John J
Langer, Robert
Kohane, Daniel S
Date Issued
November 2012
Journal
Biomaterials
Publisher
Elsevier BV
Citation
Khoo, Xiaojuan et al., "Formulations for trans-tympanic antibiotic delivery." Biomaterials 34, 4 (January 2013): p. 1281-88 doi. 10.1016/j.biomaterials.2012.10.025 ©2012 Authors
Version
Author's final manuscript
Abstract
We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases. ©2012 Elsevier Ltd.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.biomaterials.2012.10.025
