Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory
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Tonegawa_Entorhinal cortical.pdf
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Author(s)
Kitch, Lacey J.
Schnitzer, Mark J.
Kitamura, Takashi
Sun, Chen
Martin, Jared
Tonegawa, Susumu
Date Issued
September 2015
Journal
Neuron
Publisher
Elsevier/Cell Press
Citation
Kitamura, Takashi; Sun, Chen; Martin, Jared; Kitch, Lacey J.; Schnitzer, Mark J. and Tonegawa, Susumu. “Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory.” Neuron 87, no. 6 (September 2015): 1317–1331 © 2015 Elsevier Inc
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Author's final manuscript
Abstract
Forming distinct representations and memories of multiple contexts and episodes is thought to be a crucial function of the hippocampal-entorhinal cortical network. The hippocampal dentate gyrus (DG) and CA3 are known to contribute to these functions, but the role of the entorhinal cortex (EC) is poorly understood. Here, we show that Ocean cells, excitatory stellate neurons in the medial EC layer II projecting into DG and CA3, rapidly form a distinct representation of a novel context and drive context-specific activation of downstream CA3 cells as well as context-specific fear memory. In contrast, Island cells, excitatory pyramidal neurons in the medial EC layer II projecting into CA1, are indifferent to context-specific encoding or memory. On the other hand, Ocean cells are dispensable for temporal association learning, for which Island cells are crucial. Together, the two excitatory medial EC layer II inputs to the hippocampus have complementary roles in episodic memory.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2015.08.036
