Cerebral Organoid Models for Neurotropic Viruses
Name
nihms-1559238.pdf
Description
Accepted version
Size
725.5 KB
Format
Unknown
Checksum (MD5)
252d2397163e7a7c5d0bd5e1355ea6fe
Author(s)
Antonucci, Jenna M
Gehrke, Lee
Date Issued
2019
Journal
ACS Infectious Diseases
Publisher
American Chemical Society (ACS)
Citation
Antonucci, Jenna and Gehrke, Lee. 2019. "Cerebral Organoid Models for Neurotropic Viruses." ACS Infectious Diseases, 5 (12).
Version
Author's final manuscript
Abstract
Copyright © 2019 American Chemical Society. Across zoonotic pathogens, RNA viruses are responsible for disproportionate levels of human disease, suffering, and death. Neurotropic RNA viruses (e.g., rabies, Japanese and Eastern Equine Encephalitis, Ebola, West Nile, Powassan) infect the brain and spinal cord, causing meningitis, encephalitis, microcephaly, and Guillain-Barré syndrome. Mechanistic data explaining the molecular mechanisms of these diseases are lacking, and the enclosure of the central nervous system and the associated meninges in bone complicates access for diagnosis, clinical treatment, and research. Here, we discuss new tissue models, imaging methods, and molecular techniques that are changing research aimed at understanding the pathogenesis of neurotropic RNA viruses.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ACSINFECDIS.9B00339
