Enantioselective Alkenylation via Nickel-Catalyzed Cross-Coupling with Organozirconium Reagents
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Author(s)
Lou, Sha
Fu, Gregory C.
Date Issued
March 2010
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society
Citation
Lou, Sha, and Gregory C. Fu. “Enantioselective Alkenylation via Nickel-Catalyzed Cross-Coupling with Organozirconium Reagents.” Journal of the American Chemical Society 132.14 (2010) : 5010-5011.
Version
Author's final manuscript
Abstract
A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary α-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon−carbon bond-forming process that generates potentially labile β,γ-unsaturated ketones with good enantioselectivity.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja1017046
