Exploiting synthetic lethal interactions for targeted cancer therapy
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Hemann_Exploiting synthetic.pdf
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427.97 KB
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Author(s)
Reinhardt, H. Christian
Jiang, Hai
Hemann, Michael
Yaffe, Michael B
Date Issued
October 2009
Journal
Cell Cycle
Publisher
Landes Bioscience
Citation
Reinhardt, H. Christian et al. “Exploiting Synthetic Lethal Interactions for Targeted Cancer Therapy.” Cell Cycle 8.19 (2009): 3112–3119.
Version
Author's final manuscript
Abstract
Emerging data suggests that synthetic lethal interactions between mutated oncogenes/tumor suppressor genes and molecules involved in DNA damage signaling and repair can be therapeutically exploited to preferentially kill tumor cells. In this review, we discuss the concept of synthetic lethality, and describe several recent examples in which this concept was successfully implemented to target tumor cells in culture, in mouse models, and in human cancer patients.
Description
March 15, 2011
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.4161/cc.8.19.9626
