High throughput screening for discovery of materials that control stem cell fate
Name
Anderson_High throughput.pdf
Size
1.7 MB
Format
Adobe PDF
Checksum (MD5)
0a6f899e9c31c7d87c6215e0d7a8b6ff
Author(s)
Celiz, Adam D.
Davies, Martyn C.
Denning, Chris
Alexander, Morgan R.
Tibbitt, Mark W
Langer, Robert S
Anderson, Daniel Griffith
Patel, Asha
Date Issued
January 2016
Journal
Current Opinion in Solid State and Materials Science
Publisher
Elsevier
Citation
Patel, Asha K. et al. “High Throughput Screening for Discovery of Materials That Control Stem Cell Fate.” Current Opinion in Solid State and Materials Science 20.4 (2016): 202–211.
Version
Final published version
Abstract
Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cossms.2016.02.002
