Enzyme responsive acetaminophen hydrogels
Name
Vemula-2009-Enzyme Responsive Acetaminophen Hydrogels.pdf
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2.15 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Vemula, Praveen
Cruikshank, Gregory
John, George
Karp, Jeffrey Michael
Date Issued
May 2009
Journal
Proceedings of the 2009 IEEE 35th Annual Northeast Bioengineering Conference
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Citation
Vemula, Praveen Kumar et al. “Enzyme Responsive Acetaminophen Hydrogels.” IEEE, 2009. 1–2. © 2009 IEEE
Version
Final published version
Abstract
Utilization of enzyme catalysis as a tool to disassemble self-assembled hydrogels to control the release encapsulated drug provides an opportunity to design a wide range of enzyme-specific low-molecular-weight hydrogelators (LMWGs). Herein, we report a novel approach for controlled delivery of multiple drugs by an enzyme triggered hydrogel degradation mechanism. In this proof-of-concept work, we report the synthesis of LMWGs (amphiphiles) from well-known drug acetaminophen (which is known as Tylenolreg), and their ability to self-assemble into nanoscale structures in aqueous solutions to form hydrogels that subsequently encapsulate a second drug such as curcumin which is a known chemopreventive hydrophobic drug. Upon enzyme triggered degradation, hydrogels showed single and double drug delivery at physiological conditions in vitro. After treating with prodrug amphiphiles, mesenchymal stem cells (MSCs) retain their stem cell properties such as maintaining their adhesive and proliferation capacities with high viability. This new platform approach will have prospective effect on hydrogel based drug delivery research through developing drug delivery vehicles from a wide range of prodrug-based gelators.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1109/NEBC.2009.4967713
