Microbiome and Metabolome Insights into the Role of the Gastrointestinal–Brain Axis in Parkinson’s and Alzheimer’s Disease: Unveiling Potential Therapeutic Targets
Name
metabolites-12-01222.pdf
Size
1.4 MB
Format
Adobe PDF
Checksum (MD5)
c051316223f5d6544bad3a3b1b0c4d0e
Author(s)
Zacharias, Helena U.
Kaleta, Christoph
Cossais, François
Schaeffer, Eva
Berndt, Henry
Best, Lena
Dost, Thomas
Glüsing, Svea
Groussin, Mathieu
Poyet, Mathilde
Date Issued
December 5, 2022
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Metabolites 12 (12): 1222 (2022)
Version
Final published version
Abstract
Neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s disease (AD), the prevalence of which is rapidly rising due to an aging world population and westernization of lifestyles, are expected to put a strong socioeconomic burden on health systems worldwide. Clinical trials of therapies against PD and AD have only shown limited success so far. Therefore, research has extended its scope to a systems medicine point of view, with a particular focus on the gastrointestinal–brain axis as a potential main actor in disease development and progression. Microbiome and metabolome studies have already revealed important insights into disease mechanisms. Both the microbiome and metabolome can be easily manipulated by dietary and lifestyle interventions, and might thus offer novel, readily available therapeutic options to prevent the onset as well as the progression of PD and AD. This review summarizes our current knowledge on the interplay between microbiota, metabolites, and neurodegeneration along the gastrointestinal–brain axis. We further illustrate state-of-the art methods of microbiome and metabolome research as well as metabolic modeling that facilitate the identification of disease pathomechanisms. We conclude with therapeutic options to modulate microbiome composition to prevent or delay neurodegeneration and illustrate potential future research directions to fight PD and AD.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/metabo12121222
