Differential Spleen Remodeling Associated with Different Levels of Parasite Virulence Controls Disease Outcome in Malaria Parasite Infections
Name
mSphere-2015-Huang-e00018-15.full.pdf
Description
Published version
Size
2.23 MB
Format
Adobe PDF
Checksum (MD5)
910cbdda048db8b30cfc6530989940af
Author(s)
Huang, Ximei
Huang, Sha
Ong, Lai Chun
Lim, Jason Chu-Shern
Hurst, Rebecca Joan Mary
Mushunje, Annals Tatenda
Matsudaira, Paul Thomas
Han, Jongyoon
Preiser, Peter Rainer
Date Issued
2016
Journal
mSphere
Publisher
American Society for Microbiology
Version
Final published version
Abstract
© 2015 Huang et al. Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild symptoms to death. Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virulence. Using virulent and avirulent strains of the rodent malaria parasite Plasmodium yoelii, we investigated how parasite virulence modulates overall spleen function. Following parasite invasion, a difference in parasite virulence was observed in association with different levels of spleen morphology and iRBC rigidity, both of which contributed to enhanced parasite clearance. Moreover, iRBC rigidity as modulated by the spleen was demonstrated to correlate with disease outcome and thus can be used as a robust indicator of virulence. The data indicate that alterations in the biomechanical properties of iRBCs are the result of the complex interaction between host and parasite. Furthermore, we confirmed that early spleen responses are a key factor in directing the clinical outcome of an infection.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Biological Engineering
Singapore-MIT Alliance in Research and Technology (SMART)
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1128/MSPHERE.00018-15
