Nanomedicines for endothelial disorders
Name
Langer_Nanomedicines for Endothelial Disorders.pdf
Size
2.3 MB
Format
Adobe PDF
Checksum (MD5)
13d1a17fe142092ac26f98f0728cacaa
Author(s)
Toth, Michael J.
Sei, Yoshitaka J.
Mulder, Willem J.M.
Fayad, Zahi A.
Farokhzad, Omid C.
Kim, YongTae
Lee Chung, Bomy
Kamaly, Nazila
Langer, Robert S
Becraft, Jacob Robert
Date Issued
January 2016
Journal
Nano Today
Publisher
Elsevier
Citation
Lee Chung, et al. “Nanomedicines for Endothelial Disorders.” Nano Today 10, 6 (December 2015): 759–776 © 2015 Elsevier Ltd
Version
Author's final manuscript
Abstract
The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications. Keywords: Endothelium; Nanomedicine; Endothelial disorder; Diabetes; Atherosclerosis; Cancer
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.NANTOD.2015.11.009
