Microfluidic in vivo screen identifies compounds enhancing neuronal
Name
Rohde-2009-Microfluidic in vivo.pdf
Size
791.75 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Haggarty, Stephen J.
Norton, Stephanie
Samara, Chrysanthi
Gilleland, Cody Lee
Rohde, Christopher Benjamin
Yanik, Mehmet Fatih
Alternative Title
Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration
Date Issued
November 2009
Journal
Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009. EMBC 2009.
Publisher
Institute of Electrical and Electronics Engineers
Citation
Rohde, C.B. et al. “Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration.” Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE. 2009. 5950-5952. © 2009 Institute of Electrical and Electronics Engineers
Version
Final published version
Abstract
Compound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens for compounds enhancing neuronal regeneration. These screens are enabled by the microfluidic devices we have developed for C. elegans. The devices enable rapid and repeatable animal immobilization which allows high-throughput and precise surgery. Following surgery, animals are exposed to the contents of a small-molecule library and assayed for neuronal regeneration. Using this screening method we have identified several compounds that enhance neural regeneration in vivo.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
http://dx.doi.org/10.1109/IEMBS.2009.5334771
