Characterizing Failure Modes in Continuous Flow Microfluidic Pumps
Name
jia-delacelj-sb-meche-2023-thesis.pdf
Description
Thesis PDF
Size
16.67 MB
Format
Adobe PDF
Checksum (MD5)
e3a0f0c4720b1e600376dd5c40527a45
Author(s)
Jia, Delace (Delace L.)
Advisor(s)
Kamm, Roger D.
Date Issued
June 2023
Publisher
Massachusetts Institute of Technology
Abstract
Microphysiological systems provide novel platforms for drug testing and therapeutic target discovery, through their three-dimensional morphologies that mimic specific tissues and organs. In concurrence with these systems, microfluidic channels allow for a sufficient supply of nutrients to the cell culture; by creating pressure gradients across the system, they allow for fluid flow through the tissue medium. A microfluidic pump, Microheart, for continuous flow through microphysiological systems was presented in Offeddu, 2021. The design introduced a novel, low-cost method of delivering cell culture media at low flow rates. While the Microheart pumps in practice have qualitatively provided an indication of media flow through microphysiological systems, the yield rate of production, and efficacy of their function have not been fully characterized. The following study explores the potential failure modes of the Microheart pump, and characterizes the pump consistency over the standard time of function with cell cultures.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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