Combined Oxypalladation/C-H Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes
Name
Buchwald_Combined oxypalladation.pdf
Size
1.42 MB
Format
Adobe PDF
Checksum (MD5)
30305ef85e9572045086c9ff1191f471
Author(s)
Zhu, Rong
Buchwald, Stephen Leffler
Date Issued
January 2012
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Zhu, Rong, and Stephen L. Buchwald. “Combined Oxypalladation/C-H Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes.” Angewandte Chemie International Edition 51, no. 8 (February 20, 2012): 1926-1929.
Version
Author's final manuscript
Abstract
An efficient protocol has been developed for the intramolecular oxidative oxyarylation using a Pd[superscript II]-catalyzed tandem oxypalladation/C-H functionalization strategy. This methodology allows rapid access to tetrahydro-2H-indeno-[2,1-b]furan frameworks from simple hydroxyalkenes. The reactivity of this process is orthogonal to that of Pd[superscript 0]-catalyzed transformations, enabling the divergent modification of a single molecule.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/anie.201108129
