Role of MUC5B during Group B Streptococcal Vaginal Colonization
Name
mbio.00039-22.pdf
Description
Published version
Size
1.19 MB
Format
Adobe PDF
Checksum (MD5)
33c078b93841a6bdb0a649a00cd9989e
Author(s)
Burcham, Lindsey R
Bath, Jade R
Werlang, Caroline A
Lyon, Laurie M
Liu, Naoko
Evans, Christopher
Ribbeck, Katharina
Doran, Kelly S
Date Issued
2022
Journal
mBio
Publisher
American Society for Microbiology
Citation
Burcham, Lindsey R, Bath, Jade R, Werlang, Caroline A, Lyon, Laurie M, Liu, Naoko et al. 2022. "Role of MUC5B during Group B Streptococcal Vaginal Colonization." mBio, 13 (2).
Version
Final published version
Abstract
Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group B Streptococcus (GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can ascend to the uterus to cause preterm birth and fetal infection in utero. Here we show that a prominent mucin found in the FRT, MUC5B, promotes host defense by inhibiting GBS interaction with epithelial cells found in the FRT and ascension from the vagina to the uterus in vivo .
Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group B Streptococcus (GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can ascend to the uterus to cause preterm birth and fetal infection in utero. Here we show that a prominent mucin found in the FRT, MUC5B, promotes host defense by inhibiting GBS interaction with epithelial cells found in the FRT and ascension from the vagina to the uterus in vivo .
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1128/MBIO.00039-22
