Brain Differences Between Persistent and Remitted Attention-Deficit/Hyperactivity Disorder
Name
Mattfeld_etal_BRAIN_manuscript_REPORTrevision_FINAL.pdf
Size
3.24 MB
Format
Adobe PDF
Checksum (MD5)
7e4f127be1c66c8cc2b32c2c0873e4e2
Author(s)
Mattfeld, Aaron T.
Gabrieli, John D. E.
Biederman, Joseph
Spencer, Thomas
Brown, Ariel
Kotte, Amelia
Kagan, Elana
Gabrieli, Susan
Alternative Title
Brain differences between persistent and remitted attention deficit hyperactivity disorder
Date Issued
June 2014
Journal
Brain
Publisher
Oxford University Press
Citation
Mattfeld, A. T., J. D. E. Gabrieli, J. Biederman, T. Spencer, A. Brown, A. Kotte, E. Kagan, and S. Whitfield-Gabrieli. “Brain Differences Between Persistent and Remitted Attention Deficit Hyperactivity Disorder.” Brain (June 10, 2014). p.1-6.
Version
Author's final manuscript
Abstract
Previous resting state studies examining the brain basis of attention deficit hyperactivity disorder have not distinguished between patients who persist versus those who remit from the diagnosis as adults. To characterize the neurobiological differences and similarities of persistence and remittance, we performed resting state functional magnetic resonance imaging in individuals who had been longitudinally and uniformly characterized as having or not having attention deficit hyperactivity disorder in childhood and again in adulthood (16 years after baseline assessment). Intrinsic functional brain organization was measured in patients who had a persistent diagnosis in childhood and adulthood (n = 13), in patients who met diagnosis in childhood but not in adulthood (n = 22), and in control participants who never had attention deficit hyperactivity disorder (n = 17). A positive functional correlation between posterior cingulate and medial prefrontal cortices, major components of the default-mode network, was reduced only in patients whose diagnosis persisted into adulthood. A negative functional correlation between medial and dorsolateral prefrontal cortices was reduced in both persistent and remitted patients. The neurobiological dissociation between the persistence and remittance of attention deficit hyperactivity disorder may provide a framework for the relation between the clinical diagnosis, which indicates the need for treatment, and additional deficits that are common, such as executive dysfunctions.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1093/brain/awu137
