Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates
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Author(s)
Teverovskiy, Georgiy
Park, Nathaniel Hamilton
Buchwald, Stephen Leffler
Date Issued
November 2013
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Park, Nathaniel H., Georgiy Teverovskiy, and Stephen L. Buchwald. “Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates.” Org. Lett. 16, no. 1 (January 3, 2014): 220–223.
Version
Author's final manuscript
Abstract
A new air-stable nickel precatalyst for C–N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C–N bond formation to include both a wide range of aryl and heteroaryl electrophiles and aryl, heteroaryl, and alkylamines. The catalyst system is also compatible with a weak base, allowing the amination of substrates containing base-sensitive functional groups.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ol403209k
