Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination
Name
drosophila-fog-cta-and-t48-pathways-have-overlapping-and-distinct-contributions-to-mesoderm-invagination.pdf
Description
Published version
Size
8.49 MB
Format
Adobe PDF
Checksum (MD5)
1f566c62b7e93de3214b71de950d7060
Author(s)
Horo, Uzuki
Clarke, D Nathaniel
Martin, Adam C
Date Issued
May 1, 2024
Journal
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Citation
Horo, Uzuki, Clarke, D Nathaniel and Martin, Adam C. 2024. "Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination." Molecular Biology of the Cell, 35 (5).
Version
Final published version
Abstract
The regulation of the cytoskeleton by multiple signaling pathways, sometimes in parallel, is a common principle of morphogenesis. A classic example of regulation by parallel pathways is Drosophila gastrulation, where the inputs from the Folded gastrulation (Fog)/Concertina (Cta) and the T48 pathways induce apical constriction and mesoderm invagination. Whether there are distinct roles for these separate pathways in regulating the complex spatial and temporal patterns of cytoskeletal activity that accompany early embryo development is still poorly understood. We investigated the roles of the Fog/Cta and T48 pathways and found that, by themselves, the Cta and T48 pathways both promote timely mesoderm invagination and apical myosin II accumulation, with Cta being required for timely cell shape change ahead of mitotic cell division. We also identified distinct functions of T48 and Cta in regulating cellularization and the uniformity of the apical myosin II network, respectively. Our results demonstrate that both redundant and distinct functions for the Fog/Cta and T48 pathways exist.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-ShareAlike
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DOI of Published Version
https://doi.org/10.1091/mbc.E24-02-0050
