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The cortical connectome of primate lateral prefrontal cortex
Name
PIIS0896627321007868.pdf
Description
Published version
Size
6.11 MB
Format
Adobe PDF
Checksum (MD5)
e6e8495eec2a47c5b0a8bd245b339c68
Author(s)
Xu, Rui
Bichot, Narcisse P
Takahashi, Atsushi
Desimone, Robert
Date Issued
November 2021
Journal
Neuron
Publisher
Elsevier BV
Citation
Xu, Rui, Bichot, Narcisse P, Takahashi, Atsushi and Desimone, Robert. 2021. "The cortical connectome of primate lateral prefrontal cortex." Neuron.
Version
Final published version
Abstract
The lateral prefrontal cortex (LPFC) of primates plays an important role in executive control, but how it interacts with the rest of the cortex remains unclear. To address this, we densely mapped the cortical connectome of LPFC, using electrical microstimulation combined with functional MRI (EM-fMRI). We found isomorphic mappings between LPFC and five major processing domains composing most of the cerebral cortex except early sensory and motor areas. An LPFC grid of ∼200 stimulation sites topographically mapped to separate grids of activation sites in the five domains, coarsely resembling how the visual cortex maps the retina. The temporal and parietal maps largely overlapped in LPFC, suggesting topographically organized convergence of the ventral and dorsal streams, and the other maps overlapped at least partially. Thus, the LPFC contains overlapping, millimeter-scale maps that mirror the organization of major cortical processing domains, supporting LPFC's role in coordinating activity within and across these domains.
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1016/j.neuron.2021.10.018
