7.346 Cellular Garbage Disposal: Misfolded Proteins in Normal Biology and Human Disease, Fall 2011
Author(s)
Sanyal, Sumana
Alternative Title
Cellular Garbage Disposal: Misfolded Proteins in Normal Biology and Human Disease
Date Issued
December 2011
Abstract
The endoplasmic reticulum (ER) orchestrates different cellular processes by which proteins are synthesized, correctly folded, modified and ultimately transported to their final destinations. As part of this crucial biosynthetic process, proteins that are not properly folded and consequently detrimental to normal cellular function are constantly generated. A common signature of many neurodegenerative diseases, including Alzheimer's and Parkinson's, is accumulation and deposition of misfolded proteins that arise when the ability of cells to deal with the burden of misfolded proteins is compromised. In this course, we will explore how the ER quality control machinery ensures that only properly assembled proteins exit the ER while distinguishing between nascent proteins en route to their biologically active folded state from those that are terminally misfolded.
Subjects
proteins
misfolded
endoplasmic reticulum
ER
protein degradation
cytosol
cell cycle
proteasomes
MIT Department
Massachusetts Institute of Technology. Department of Biology
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