The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer
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Kellis_The Tasmanian.pdf
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Author(s)
Murchison, Elizabeth P.
Tovar, Cesar
Hsu, Arthur
Bender, Hannah S.
Kheradpour, Pouya
Rebbeck, Clare A.
Obendorf, David
Conlan, Carly
Bahlo, Melanie
Blizzard, Catherine A.
Date Issued
December 2009
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Murchison, E. P., C. Tovar, A. Hsu, H. S. Bender, P. Kheradpour, C. A. Rebbeck, D. Obendorf, et al. “The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer.” Science 327, no. 5961 (January 1, 2010): 84–87.
Version
Author's final manuscript
Abstract
The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.1180616
