The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System
Name
Cholewa-Waclaw-2016-The Role of Epigenetic Mec.pdf
Size
494.52 KB
Format
Adobe PDF
Checksum (MD5)
aeee424a50c2586c53c9afead7cdb9ef
Author(s)
Cholewa-Waclaw, Justyna
Bird, Adrian
von Schimmelmann, Melanie
Schaefer, Anne
Yu, Huimei
Song, Hongjun
Madabhushi, Ram
Tsai, Li-Huei
Date Issued
November 2016
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Cholewa-Waclaw, Justyna; Bird, Adrian; von Schimmelmann, Melanie; Schaefer, Anne; Yu, Huimei; Song, Hongjun; Madabhushi, Ram and Tsai, Li-Huei. “The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System.” The Journal of Neuroscience 36, no. 45 (November 2016): 11427–11434 © 2016 The Authors
Version
Final published version
Abstract
Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic mechanism of gene expression regulation in various postmitotic neurons, both over time and in response to environmental stimuli. In addition to its fundamental contribution to our understanding of basic neuronal physiology, alterations in these neuroepigenetic mechanisms have been recently linked to numerous neurodevelopmental, psychiatric, and neurodegenerative disorders. This article provides a selective review of the role of DNA and histone modifications in neuronal signal-induced gene expression regulation, plasticity, and survival and how targeting these mechanisms could advance the development of future therapies. In addition, we discuss a recent discovery on how double-strand breaks of genomic DNA mediate the rapid induction of activity-dependent gene expression in neurons.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1523/JNEUROSCI.2492-16.2016
