Famine versus feast: understanding the metabolism of tumors in vivo
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Famine versus feast.pdf
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607.87 KB
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Author(s)
Vander Heiden, Matthew G.
Mayers, Jared R.
Date Issued
January 2015
Journal
Trends in Biochemical Sciences
Publisher
Elsevier
Citation
Mayers, Jared R., and Matthew G. Vander Heiden. “Famine versus Feast: Understanding the Metabolism of Tumors in Vivo.” Trends in Biochemical Sciences 40.3 (2015): 130–140.
Version
Author's final manuscript
Abstract
To fuel unregulated proliferation, cancer cells alter metabolism to support macromolecule biosynthesis. Cell culture studies have revealed how different oncogenic mutations and nutrients impact metabolism. Glucose and glutamine are the primary fuels used in vitro; however, recent
studies have suggested that utilization of other amino acids as well as lipids and protein can also be important to cancer cells. Early investigations of tumor metabolism are translating these findings to the biology of whole tumors and suggest that additional complexity exists beyond nutrient availability alone in vivo. Whole body metabolism and tumor heterogeneity also influence the metabolism of tumor cells, and successful targeting of metabolism for cancer therapy will require an understanding of tumor metabolism in vivo.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.tibs.2015.01.004
