Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity
Name
Kaplan-2016-Contrasting roles fo.pdf
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3.38 MB
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Author(s)
Thomazeau, Aurore
Kaplan, Eitan S.
Cooke, Samuel Frazer
Komorowski, Robert
Chubykin, Alexander A.
Khibnik, Lena A.
Gavornik, Jeffrey P.
Bear, Mark
Date Issued
March 2016
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Kaplan, Eitan S, Sam F Cooke, Robert W Komorowski, Alexander A Chubykin, Aurore Thomazeau, Lena A Khibnik, Jeffrey P Gavornik, and Mark F Bear. “Contrasting Roles for Parvalbumin-Expressing Inhibitory Neurons in Two Forms of Adult Visual Cortical Plasticity.” eLife 5 (March 4, 2016).
Version
Final published version
Abstract
The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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DOI of Published Version
https://doi.org/10.7554/eLife.11450
