Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species
Name
24760.full.pdf
Description
Published version
Size
2.59 MB
Format
Adobe PDF
Checksum (MD5)
93bc9182a42ab5cb552f155519f28b01
Author(s)
Shen, Zeli
Fox, James G.
Date Issued
November 18, 2019
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
Proceedings of the National Academy of Sciences
Citation
Bostick, John W. et al. “Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species.” Proceedings of the National Academy of Sciences of the United States of America 116 (2019): 24760-24769 © 2019 The Author(s)
Version
Final published version
Abstract
Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two Helicobacter species, Helicobacter apodemus and Helicobacter typhlonius, isolated from immunocompromised mice. We demonstrated that the introduction of both Helicobacter species activated ILCs and induced gut inflammation; however, these Helicobacter species negatively regulated RORγt+ group 3 ILCs (ILC3s), especially T-bet+ ILC3s, and diminished their proliferative capacity. Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by Helicobacter species, and may serve as a model for further investigations to elucidate the host–microbe interactions that critically sustain the maintenance of intestinal ILC3s.
Subjects
Multidisciplinary
MIT Department
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1073/pnas.1908128116
