Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins
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Karnik_Polymeric nanoparticles.pdf
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1.32 MB
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Author(s)
Zhu, Xi
Wu, Jun
Shan, Wei
Tao, Wei
Zhao, Lili
Lim, Jong-Min
D'Ortenzio, Mathew
Karnik, Rohit
Huang, Yuan
Shi, Jinjun
Date Issued
February 2016
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Zhu, Xi et al. “Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins.” Angewandte Chemie International Edition 55.10 (2016): 3309–3312.
Version
Author's final manuscript
Abstract
Effective delivery of therapeutic proteins is a formidable challenge. Herein, using a unique polymer family with a wide-ranging set of cationic and hydrophobic features, we developed a novel nanoparticle (NP) platform capable of installing protein ligands on the particle surface and simultaneously carrying therapeutic proteins inside by a self-assembly procedure. The loaded therapeutic proteins (e.g., insulin) within the NPs exhibited sustained and tunable release, while the surface-coated protein ligands (e.g., transferrin) were demonstrated to alter the NP cellular behaviors. In vivo results revealed that the transferrin-coated NPs can effectively be transported across the intestinal epithelium for oral insulin delivery, leading to a notable hypoglycemic response.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/anie.201509183
